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生物网络分析

Analysis of Biological Networks
课程网址: http://ocw.mit.edu/courses/biological-engineering/20-440-analysis...  
主讲教师: John Essigmann; Ram Sasisekharan
开课单位: 麻省理工学院
开课时间: 2004-01-01
课程语种: 英语
中文简介:
本课程从分子,细胞,细胞外和器官层次分析复杂的生物过程。重点放在管理这些过程的基本生化和生物物理原理上。待研究的方法的实例包括趋化性,氮固定到有机生物分子中,生长因子和激素介导的信号级联,以及导致细胞死亡以响应DNA损伤的信号级联。在每种情况下,资源的可用性或刺激的存在导致一些生化途径被打开而其他生物化学途径被关闭。该课程检查这些过程的动态方面,并详细说明生化机制主题如何影响分子/细胞/组织/器官水平功能。强调了作为生物网络的多种途径相互作用的化学和定量观点。学生工作最终在生物网络领域准备独特的资助申请。
课程简介: This class analyzes complex biological processes from the molecular, cellular, extracellular, and organ levels of hierarchy. Emphasis is placed on the basic biochemical and biophysical principles that govern these processes. Examples of processes to be studied include chemotaxis, the fixation of nitrogen into organic biological molecules, growth factor and hormone mediated signaling cascades, and signaling cascades leading to cell death in response to DNA damage. In each case, the availability of a resource, or the presence of a stimulus, results in some biochemical pathways being turned on while others are turned off. The course examines the dynamic aspects of these processes and details how biochemical mechanistic themes impinge on molecular/cellular/tissue/organ-level functions. Chemical and quantitative views of the interplay of multiple pathways as biological networks are emphasized. Student work culminates in the preparation of a unique grant application in an area of biological networks.
关 键 词: 分子; 细胞; 细胞外
课程来源: 麻省理工学院公开课
最后编审: 2020-10-16:yumf
阅读次数: 50