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蛋白质折叠，错误折叠和人类疾病
7.343 Protein Folding, Misfolding and Human Disease |
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| 课程网址: |
http://ocw.mit.edu/courses/biology/7-343-protein-folding-misfoldi...
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| 主讲教师: |
Dr. Melissa Kosinski-Collins
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| 开课单位: |
麻省理工学院
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| 开课时间: |
2004-01-01
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| 课程语种: |
英语
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| 中文简介: |
本课程是麻省理工学院生物系提供的众多高级本科生研讨会之一。这些研讨会是为有兴趣利用初级研究文献在高度互动的环境中讨论和了解当前生物研究的学生量身定制的。本课程的讲师是 kosinski-柯林斯博士, 是 hhmi 教育集团的成员。维持细胞中蛋白质所采用的复杂的三维结构对功能至关重要。通常情况下, 由于环境压力、基因突变和感染, 蛋白质的折叠结构会发生改变, 多个蛋白质会在一个被称为聚集的过程中粘附和脱落。在许多蛋白质聚集疾病中, 错误地折叠蛋白质自我关联, 形成纤维样聚集物, 导致脑细胞死亡和痴呆。在这个过程中, 从牛海绵状脑病 (疯牛病)、克里茨菲德-雅氏病和库鲁病在内的灵长类疾病的分子和生化基础进行检查。还讨论了其他类别的错误折叠疾病, 如阿尔茨海默氏症和亨廷顿病。所有这些疾病所涉及的蛋白质, 以及蛋白质在这些疾病过程中的三维结构如何变化, 以及为什么某些物种的灵长类动物不能根据蛋白质序列感染来自其他物种的动物和结构。然后, 该课程将讨论治疗一些蛋白质聚集疾病的可能检测方法和疗法。
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| 课程简介: |
This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. The instructor for this course, Dr. Kosinski-Collins, is a member of the HHMI Education Group. Maintenance of the complex three-dimensional structure adopted by a protein in the cell is vital for function. Oftentimes, as a consequence of environmental stress, genetic mutation, and/or infection, the folded structure of a protein gets altered and multiple proteins stick and fall out of solution in a process known as aggregation. In many protein aggregation diseases, incorrectly folded proteins self-associate, forming fiber-like aggregates that cause brain cell death and dementia. In this course, the molecular and biochemical basis of the prion diseases, which include bovine spongiform encephalopathy (mad cow disease), Creutzfedt-Jakob disease and kuru will be examined. Also discussed are other classes of misfolding diseases such as Alzheimer's disease and Huntington's disease. The proteins involved in all of these disorders and how the proteins' three dimensional structures change during the course of these afflictions is covered as well as why prions from certain species cannot infect animals from other species based on protein sequence and structure. The course will then address possible detection methods and therapies that are under development to treat some of the protein aggregation diseases.
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| 关 键 词: |
蛋白质聚集; 自缔合; 细胞死亡; 牛海绵状脑病; 蛋白质结构
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| 课程来源: |
麻省理工学院公开课
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| 最后编审: |
2016-03-20：gmj
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| 阅读次数: |
40
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