开课单位--耶鲁大学

121
Lecture 14 - Epoxide Opening, Dipolar Cycloaddition, and Ozonolysis[第14讲-环氧化物开环、偶极环加成和臭氧分解]
   J. Michael McBride(耶鲁大学) The formation of epoxides and the regiospecificity of their acid- and base-catalyzed ring openings underlines the importance of thinking carefully abo...
热度：76

122
Lecture 3 - Rate and Selectivity in Radical-Chain Reactions[第三讲-自由基链式反应的速率和选择性]
   J. Michael McBride(耶鲁大学) The reactivity-selectivity principle explains why bromine atoms are more selective that chlorine atoms in abstracting hydrogen atoms from carbon. A fr...
热度：59

123
Lecture 33 - Green Chemistry; Acids and Acid Derivatives[第33讲-绿色化学；酸和酸衍生物]
   J. Michael McBride(耶鲁大学) Green chemistry needs new asymmetric reactions and safer, more environmental Mitsunobu reactions. The Mitsunobu mechanism is general and reliable, but...
热度：64

124
Lecture 5 - Solvation, H-Bonding, and Ionophores[第5讲-溶剂化、氢键和离子载体]
   J. Michael McBride(耶鲁大学) Most organic reactions occur in solution, and particularly in the case of ions, one must consider non-bonded interactions with neighboring molecules. ...
热度：62

125
Lecture 30 - Oxidation States and Mechanisms[第30讲-氧化状态和机理]
   J. Michael McBride(耶鲁大学) A difficult exam question shows how visible and NMR spectroscopy related to long-term misassignment of the structure for the triphenylmethyl dimer. Ev...
热度：38

126
Lecture 13 - Addition to Form Three-Membered Rings: Carbenoids and Epoxidation[第13讲-形成三元环的加成反应：类卡宾和环氧化]
   J. Michael McBride(耶鲁大学) After drill on the mechanism of the pinacol rearrangement, this lecture applies molecular-orbital analysis to simultaneous electrophilic/nucleophilic ...
热度：172

127
Lecture 6 - Brønsted Acidity and the Generality of Nucleophilic Substitution[第6讲-勃朗斯特酸度和亲核取代的普遍性]
   J. Michael McBride(耶鲁大学) The coincidentally substantial extent of ionic dissociation of water provides an example of Brønsted acidity, or nucleophilic substitution at h...
热度：52

128
Lecture 4 - Electronegativity, Bond Strength, Electrostatics, and Non-Bonded Interactions[第四讲-电负性、键强度、静电学和非键相互作用]
   J. Michael McBride(耶鲁大学) A student provides insight on fractional-order rate laws. Bonds involving atoms with lone-pair electrons are weakened by electron-pair repulsion. Elec...
热度：61

129
Lecture 2 - Peculiar Rate Laws, Bond Dissociation Energies, and Relative Reactivities[第2课-特殊速率定律、键离解能和相对反应性]
   J. Michael McBride(耶鲁大学) Curious kinetic orders can be mechanistically informative. Fractional kinetic orders suggest dissociation of a dominant aggregate to give a smaller re...
热度：58

130
Lecture 7 - Nucleophilic Substitution Tools - Stereochemistry, Rate Law, Substrate, Nucleophile, Leaving Group[第7讲-亲核取代工具-立体化学、速率定律、底物、亲核试剂、离开基团]
   J. Michael McBride(耶鲁大学) SN2 substitution provides an example of establishing the mechanism of a chemical reaction by disproving all the alternatives. Five general pathways ar...
热度：41